circRNA basic information
circBase ID: -
Name: hsa_circ_INTS4
Synonym: CircINTS4
Host Gene: hsa-miR-129-5p
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: ADR-resistant TNB cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-129-5p
Biological function: Experimental results showed that circINTS4 knockdown inhibited proliferation, migration, invasion, and autophagy.
Molecular mechanism: CIRCINTS4 regulates POM121 expression by sponge-adsorbed hsa-miR-129-5p. CIRCINTS4 knockdown prevents ADR-resistant tumor growth by regulating the hsa-miR-129-5p/POM121 axis in vivo.
Survival: -
Supported No.:
 1
Description:

CircRNA circINTS4 may act as the ceRNA of miR-129-5p to regulate the expression of target gene POM121, thereby promoting the progress of TNBC molecular mechanism and providing scientific basis for circINTS4 as a new molecular target for clinical diagnosis and drug resistance therapy of TNBC.
Other information
Title:

CircINTS4 Facilitates Chemoresistance of TNBC by Competitively Binding miR-129-5p/POM121 Axis.

Journal: J Oncol
Published: 2022/4/15
PubMed ID: 35419056