circRNA basic information
circBase ID: hsa_circ_0000854
Name: -
Synonym: Circ_0000854
Host Gene: hsa-miR-1294
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human liver immutable cell lines (THLE-2), human HCC cell lines (HCCLM3, MHCC97H, Huh-7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1294
Biological function: Silencing circ_0000854 suppressed HCC cell malignant behaviors, including proliferation, cell cycle progression, migration and invasion.
Molecular mechanism: Circ_0000854 exhibited sponge effect on hsa-miR-1294 and hsa-miR-1294 inhibition reversed function of circ_0000854 knockdown. In addition, hsa-miR-1294 targeted IRGQ and circ_0000854 sponged hsa-miR-1294 to upregulate IRGQ.
Survival: -
Supported No.:
 1
Description:

Circ_0000854 accelerated HCC progression via the miR-1294/IRGQ axis, providing a novel regulatory mechanism for HCC pathogenesis.
Other information
Title:

Circ_0000854 regulates the progression of hepatocellular carcinoma through miR-1294 /IRGQ axis.

Journal: Clin Immunol
Published: 2022/4/14
PubMed ID: 35417749