circRNA basic information
circBase ID: -
Name: hsa_circ_RFX3
Synonym: CircRFX3
Host Gene: -
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal glial cell line (HEB), human glioma cell lines (LN18, U87, U118, HS683, LN229)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: CircRFX3 knockdown led to the suppression of glioma cell and tumor growth.
Molecular mechanism: Mechanism analyses suggested that circRFX3 recruited HNRNPK to enhance RFX3 mRNA stability,
Survival: -
Supported No.:
 2
Description:

CircRFX3, as a tumor promoter, could recruit HNRNPK to stabilize RFX3 mRNA in glioma cells. Additionally, RFX3 could promote PROX1 transcription to promote glioma progression.
Other information
Title:

CircRFX3 Up-regulates Its Host Gene RFX3 to Facilitate Tumorigenesis and Progression of Glioma.

Journal: J Mol Neurosci
Published: 2022/4/14
PubMed ID: 35416616