circRNA basic information
circBase ID: -
Name: hsa_circ_CFH
Synonym: circ-CFH
Host Gene: hsa-miR-377-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cell lines (Huh7, SNU387), normal hepatic cell lines (THLE-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-377-3p
Biological function: Downregulation of circ-CFH inhibited the development of HCC by repressing cell proliferation, migration, invasion, and glycolysis while enhancing apoptosis_n vitro, as well as inhibited tumor growth_n vivo.
Molecular mechanism: Overexpression of hsa-miR-377-3p could impede the HCC process by targeting RNF38.
Survival: -
Supported No.:
 3
Description:

the circ-CFH/miR-377-3p/RNF38 axis regulated the progression of HCC cells, which might provide new diagnostic markers for HCC.
Other information
Title:

circ-CFH promotes the development of HCC by regulating cell proliferation, apoptosis, migration, invasion, and glycolysis through the miR-377-3p/RNF38 axis.

Journal: Open Life Sci
Published: 2022/4/14
PubMed ID: 35415236