circRNA basic information
circBase ID: hsa_circ_0000190
Name: -
Synonym: Circ_0000190
Host Gene: hsa-miR-1252-5p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CC cell lines (HeLa, SiHa, CaSki, C33A), normal cell line (Ect1-E6E7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1252-5p
Biological function: Overexpressed circ_0000190 attenuated CC progression_n vitro_nd_n vivo.
Molecular mechanism: Circ_0000190 functioned through the modulation of hsa-miR-1252-5p/EIF4EBP2 axis.
Survival: -
Supported No.:
 1
Description:

In our investigation, a novel tumor suppressive gene circ_0000190 was recognized, which could be treated as a promising biomarker for the diagnosis of CC.
Other information
Title:

Down-regulated Circ_0000190 promotes cervical cancer by facilitating the activity of proto-oncogene protein EIF4E.

Journal: Cell Cycle
Published: 2022/4/14
PubMed ID: 35414334