| Detected method: |
Q
|
| Detected method confidence |
High
|
| Expression pattern: |
|
| Associated gene: |
NR3C1 |
| Associated microRNA: |
hsa-miR-497a-5p |
| Biological function: |
circDYM and NR3C1 were downregulated and miR-497a-5p was upregulated in the hippocampus tissues of CUMS mice. Overexpressed circDYM alleviated CUMS mice depressive-like behavior and repressed hippocampal neurons injury. |
| Molecular mechanism: |
circDYM could upregulate NR3C1 by sponging hsa-miR-497a-5p. hsa-miR-497a-5p overexpression reversed the regulation of circDYM on CUMS mice depressive-like behavior and hippocampal neurons injury. In addition, the function of hsa-miR-497a-5p overexpression on CUMS mice depressive-like behavior and hippocampal neurons injury also could be reversed by overexpressing NR3C1. |
| Survival: |
- |
Supported
No.: |
1 |
| Description: |
circDYM could relieve the depressive-like behavior in CUMS mice and hippocampal neurons injury through miR-497a-5p/NR3C1 pathway. These data confirmed that circDYM had an anti-depressive function, which might be a potential target for depression treatment. |