circRNA basic information
circBase ID: -
Name: hsa_circ_KCNQ5
Synonym: Circ_KCNQ5
Host Gene: hsa-miR-622
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human AML cell lines (Kasumi-1, MV4-11)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-622
Biological function: The expression of circ_KCNQ5 was increased in bone marrow samples of childhood AML patients and AML cell lines. The knockdown of circ_KCNQ5 largely suppressed AML cell proliferation and promoted cell apoptosis.
Molecular mechanism: Circ_KCNQ5 directly bound to hsa-miR-622 and inhibited hsa-miR-622 expression. The cotransfection of hsa-miR-622 inhibitor reversed the effects of circ_KCNQ5 knockdown and thus recovered cell proliferation and depleted cell apoptosis. RAB10 was a target of hsa-miR-622, and circ_KCNQ5 bound to hsa-miR-622 to increase the expression of RAB10. hsa-miR-622 restoration inhibited AML cell proliferation and induced cell apoptosis, while RAB10 overexpression abolished these effects.
Survival: -
Supported No.:
 2
Description:

Circ_KCNQ5 high expression was associated with childhood AML malignant development, and circ_KCNQ5 participated in AML progression by regulating the miR-622/RAB10 pathway.
Other information
Title:

Circ_KCNQ5 participates in the progression of childhood acute myeloid leukemia by enhancing the expression of RAB10 via binding to miR-622.

Journal: Hematology
Published: 2022/4/13
PubMed ID: 35413218