circRNA basic information
circBase ID: -
Name: hsa_circ_EHD2
Synonym: circEHD2
Host Gene: hsa-miR-4731-5p
 
 
 
Disease basic information
DO ID:
 4450
DO name: renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: RCC cell lines (769P, 786-O, ACHN), human embryonic kidney cell line (HEK-293_)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ABCF2
Associated microRNA: hsa-miR-4731-5p
Biological function: increased circEHD2 in SU-resistant RCC tissues and cell lines and implicated in RCC histological grade and SU resistance. Knock-down of circEHD2 down-regulated the resistance of RCC to SUin vitroandvivo;
Molecular mechanism: circEHD2 bound to hsa-miR-4731-5p to mediate ABCF2 in RCC, ABCF2 rescued the inhibitory effect of circEHD2 knock-down on SU resistance of RCC.
Survival: -
Supported No.:
 2
Description:

circEHD2 enhances RCC resistance to SU via acting as a miR-4731-5p sponge to mediate ABCF2. MiR-4731-5p can target circEHD2 and ABCF2, thus providing a novel and effective therapeutic against renal cell carcinoma.
Other information
Title:

Circular RNA Eps15-homology domain-containing protein 2 induce resistance of renal cell carcinoma to sunitinib via microRNA-4731-5p/ABCF2 axis.

Journal: Bioengineered
Published: 2022/4/13
PubMed ID: 35412955