circRNA basic information
circBase ID: -
Name: hsa_circ_HGF
Synonym: CircHGF
Host Gene: hsa-miR-25-3p
 
 
 
Disease basic information
DO ID:
 10159
DO name: osteonecrosis
Disease details: osteonecrosis of the femoral head
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: BMSCs
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-25-3p
Biological function: The effects of a significantly upregulated circRNA, circHGF, on the proliferation and osteogenic differentiation of BMSCsin vitro.
Molecular mechanism: circHGF suppressed the proliferation and osteogenic differentiation of BMSCs in ONFH by targeting hsa-miR-25-3p/SMAD7 axis.
Survival: -
Supported No.:
 1
Description:

Our findings provided a potential diagnostic and therapeutic strategy for ONFH.
Other information
Title:

CircHGF suppressed cell proliferation and osteogenic differentiation of BMSCs in ONFH via inhibiting miR-25-3p binding to SMAD7.

Journal: Mol Ther Nucleic Acids
Published: 2022/4/12
PubMed ID: 35402073