circRNA basic information
circBase ID: -
Name: hsa_circ_FN1
Synonym: circFN1
Host Gene: hsa-miR-206
 
 
 
Disease basic information
DO ID:
 11984
DO name: hypertrophic cardiomyopathy
Disease details: hypertrophic cardiomyopathy
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: rat cardiomyocyte cell lines (H9c2, HEK293)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-206
Biological function: The targeted binding relationship between miR-206, miR-145-5p, miR-1-3p, and ACTB was found. Furthermore, ADAMTS9-AS1 and circFN1 were discovered as the upstream genes of miR-206. Moreover, ADAMTS9-AS1, circFN1, and ACTB were found to be poorly expressed, and miR-206 was highly expressed in HCM.
Molecular mechanism: In vitroexperimentation further confirmed that ADAMTS9-AS1 and circFN1 could competitively bind to hsa-miR-206, thereby augmenting ACTB expression.
Survival: -
Supported No.:
 1
Description:

ADAMTS9-AS1/circFN1-miR-206-ACTB regulatory network may involve in HCM occurrence, providing a novel theoretical basis for in-depth understanding of mechanism of HCM.
Other information
Title:

lncRNA ADAMTS9-AS1/circFN1 Competitively Binds to miR-206 to Elevate the Expression of ACTB, Thus Inducing Hypertrophic Cardiomyopathy.

Journal: Oxid Med Cell Longev
Published: 2022/4/12
PubMed ID: 35401927