circRNA basic information
circBase ID: hsa_circ_0000423
Name: -
Synonym: Circ_0000423
Host Gene: hsa-miR-525-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human CRC cells (SW480, HCT116), normal colon mucosal epithelial cells (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SGPP1
Associated microRNA: hsa-miR-525-5p
Biological function: SEV could inhibit CRC cell proliferation, migration and invasion. Circ_0000423 was upregulated in CRC and its expression could be reduced by SEV. Overexpressed circ_0000423 reversed the inhibitory effect of SEV on CRC cell proliferation, migration and invasion and the promotion effect on cell apoptosis.
Molecular mechanism: hsa-miR-525-5p could be sponged by circ_0000423, and its overexpression also abolished the regulation of circ_0000423 on the progression of SEV-treated CRC cells. In addition, SGPP1 was confirmed to be a target of hsa-miR-525-5p, and its expression was positively regulated by circ_0000423. hsa-miR-525-5p inhibitor promoted CRC cell progression under the treatment of SEV, while these effects could be overturned by SGPP1 silencing. Furthermore, the inhibition effect of SEV on CRC tumorigenesis also could be abolished by overexpressing circ_0000423.
Survival: -
Supported No.:
 1
Description:

Our results showed that SEV inhibited CRC progression through the regulation of circ_0000423/miR-525-5p/SGPP1 axis.
Other information
Title:

Sevoflurane Suppresses the Proliferation, Migration and Invasion of Colorectal Cancer Through Regulating Circ_0000423/miR-525-5p/SGPP1 Network.

Journal: Cell Mol Bioeng
Published: 2022/4/12
PubMed ID: 35401845