circRNA basic information
circBase ID: -
Name: hsa_circ_P4HB
Synonym: CircP4HB
Host Gene: hsa-miR-1184
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: lung adenocarcinoma cell lines (H1299, A549, SPCA1, H358)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1184
Biological function: CircP4HB expression levels were increased in LUAD. It triggered glutathione (GSH) synthesis and, therefore protected LUAD cells from ferroptosis induced by erastin.
Molecular mechanism: circP4HB may function as a competing endogenous RNA by modulating hsa-miR-1184 to regulate SLC7A11. CircP4HB inhibited ferroptosis by regulating hsa-miR-1184/ SLC7A11-mediated GSH synthesis. In vivo, overexpression of circP4HB promoted tumor growth and inhibited ferroptosis.
Survival: -
Supported No.:
 1
Description:

circP4HB acts as a novel ferroptosis suppressor in LUAD. Furthermore, circP4HB protects LUAD from ferroptosis via modulation of the miR-1184/SLC7A11 axis. Our findings identified circP4HB as a novel biomarker in LUAD and warrants further investigation in the early diagnosis and treatment of LUAD.
Other information
Title:

CircP4HB regulates ferroptosis via SLC7A11-mediated glutathione synthesis in lung adenocarcinoma.

Journal: Transl Lung Cancer Res
Published: 2022/4/12
PubMed ID: 35399564