circRNA basic information
circBase ID: hsa_circ_0075932
Name: -
Synonym: circRNA_0075932
Host Gene: hsa-miR-495, hsa-miR-142-3p
 
 
 
Disease basic information
DO ID:
 0050117
DO name: disease by infectious agent
Disease details: burn-associated infection
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-495, hsa-miR-142-3p
Biological function: miR-142 effectively suppressed the expression of circRNA_0075932/NLRP3 while miR-495 inhibited the expression of circRNA_0075932/PUM2.
Molecular mechanism: Downregulation of circRNA_0075932 suppressed the expression of circRNA_0075932/NLRP3/PUM2 and activated the expression of hsa-miR-142/hsa-miR-495. Exosomes collected from lenti-circRNA_0075932 shRNA-treated ADSCs showed remarkable efficiency in maintaining the post heat stress (PHS)-induced dysregulation of circRNA_0075932, hsa-miR-142, hsa-miR-495, NLRP3, PUM2, AuroraB, Ika, NF-kB, TNF-alpha, IL-1beta, and MCP-1 in THP-1 cells. Moreover, EXO-Lenti-circRNA_0075932 shRNA significantly restored burn-induced dysregulation of circRNA_0075932, hsa-miR-142, hsa-miR-495, NLRP3, PUM2, AuroraB, Ika, NF-kB, TNF-alpha, IL-1beta, and MCP-1 in obese rats.
Survival: -
Supported No.:
 1
Description:

the expression of circ_0075932 in adipose tissue is evidently increased in burn-associated infection in obese rats. Moreover, the administration of circ_0075932 shRNA exhibited a therapeutic effect upon burn-associated infection in obese rats by suppressing the expression of circ_0075932.
Other information
Title:

Administration of circRNA_0075932 shRNA exhibits a therapeutic effect on burn-associated infection in obese rats.

Journal: Biochem Biophys Res Commun
Published: 2022/4/10
PubMed ID: 35397427