circRNA basic information
circBase ID: hsa_circ_0088036
Name: -
Synonym: circRNA_0088036
Host Gene: hsa-miR-140-3p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: human BCa cells (T24, UMUC3, TCCSUP), normal bladder epithelial cells (SV-HUC-1)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-140-3p
Biological function: Upregulated expression of hsa_circRNA_0088036 in BCa tissues and cell lines was positively correlated with overall survival and clinicopathologic characteristics. Knockdown of hsa_circRNA_0088036 inhibited the growth, migration, and invasion of BCa cells both in vivo and in vitro.
Molecular mechanism: hsa_circRNA_0088036 could directly interact with hsa-miR-140-3p and act as a miRNA sponge to modulate FOXQ1 expression.
Survival: better
Supported No.:
 1
Description:

Knockdown of hsa_circRNA_0088036 inhibited the proliferation, migration, and metastasis of BCa cells via miR-140-3p/FOXQ1 signaling, suggesting that hsa_circRNA_0088036 is a potential biomarker and therapeutic target for BCa.
Other information
Title:

Hsa_circRNA_0088036 acts as a ceRNA to promote bladder cancer progression by sponging miR-140-3p.

Journal: Cell Death Dis
Published: 2022/4/10
PubMed ID: 35396504