circRNA basic information
circBase ID: hsa_circ_0004140
Name: -
Synonym: circ_0004140
Host Gene: hsa-miR-1184
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: LUAD cell lines (A549, SPCA-1, NCI-H446, NCI-H292), BEAS-2B cell line
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1184
Biological function: CircRNAs have been revealed a crucial pre-clinical diagnostic and therapeutic potentials in LUAD. Herein, we identify a novel circRNA (circ_0004140), derived from the oncogene YAP1, which is up-regulated in LUAD. The high expression of circ_0004140 is correlated with poor prognosis and CTL cells dysfunction in LUAD patients.
Molecular mechanism: Knockdown of circ_0004140 regulated LUAD cells proliferation, migration, and apoptosis. Mechanistically, circ_0004140 served as a sponge of hsa-miR-1184 targeting C-C motif chemokine ligand 22(CCL22). Overexpression of CCL22 reversed the inhibitory effect induced by si-circ_0004140 on cells proliferation and migration. Moreover, we also revealed that elevated circ_ooo4140 was related to cytotoxic lymphocyte exhaustion, and a combination therapy of C-021 (CCL22/CCR4 axis inhibitor) and anti-PD-1 attenuated LUAD promotion and immune resistance.
Survival: poor
Supported No.:
 1
Description:

circ_0004140 may drive resistance to anti-PD-1 immunotherapy, providing a novel potential therapeutic target for LUAD treatment.
Other information
Title:

circ_0004140 promotes LUAD tumor progression and immune resistance through circ_0004140/miR-1184/CCL22 axis.

Journal: Cell Death Discov
Published: 2022/4/10
PubMed ID: 35396377