circRNA basic information
circBase ID: -
Name: hsa_circ_FARSA
Synonym: circFARSA
Host Gene: hsa-miR-330-5p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: T24, UM-UC-3, 5637, J82
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-330-5p
Biological function: circFARSA expression was markedly upregulated in BC tissues and cell lines compared with that in normal bladder samples. Silencing circFARSA expression decreased BC cell proliferation, invasion, and migration but induced their apoptosis in vitro.
Molecular mechanism: Downregulating circFARSA expression slowed tumor growth in vivo and directly sponged hsa-miR-330 and inhibited its function in BC cells in vitro. Inhibiting hsa-miR-330 expression abolished the regulatory effects of circFARSA silencing on the tumor phenotypes of BC cells.
Survival: -
Supported No.:
 2
Description:

circFARSA expression is upregulated and exerts oncogenic functions in BC by sponging miR-330.
Other information
Title:

The circular RNA circFARSA sponges microRNA-330-5p in tumor cells with bladder cancer phenotype.

Journal: BMC Cancer
Published: 2022/4/10
PubMed ID: 35395756