circRNA basic information
circBase ID: hsa_circ_0000442
Name: -
Synonym: Circ_0000442
Host Gene: hsa-miR-1229-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: BC cell lines (MCF-7, T-47D), normal breast epithelial cell line (MCF-10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-1229-3p
Biological function: Circ_0000442 expression was downregulated and miR-1229-3p expression was upregulated in BC tissues and cells. Circ_0000442 directly interacted with miR-1229-3p. Circ_0000442 repressed proliferation, migration, invasion and glycolysis but promoted apoptosis in BC cells.
Molecular mechanism: The anti-tumor role of circ_0000442 was attributed to the sponge effect on hsa-miR-1229-3p. ZBTB1 was a downstream target for hsa-miR-1229-3p. Downregulation of hsa-miR-1229-3p blocked the malignant behaviors in BC cells by elevating the expression of ZBTB1. Circ_0000442 regulated the ZBTB1 level by targeting hsa-miR-1229-3p, and it inhibited tumor growth of BC in vivo by mediating the hsa-miR-1229-3p/ZBTB1 axis.
Survival: -
Supported No.:
 2
Description:

circ_0000442 impeded the progression of BC by sponging miR-1229-3p to evoke the ZBTB1 expression upregulation.
Other information
Title:

Circ_0000442 functions as a tumor repressor in breast cancer by impacting miR-1229-3p and upregulating ZBTB1.

Journal: Mamm Genome
Published: 2022/4/9
PubMed ID: 35394175