circRNA basic information
circBase ID: hsa_circ_0060640
Name: -
Synonym: circRNA_0060640
Host Gene: hsa-miR-214-3p
 
 
 
Disease basic information
DO ID:
 0070353
DO name: cataract
Disease details: posterior capsule opacification
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: hLECs cell line (SRA01/04)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-214-3p
Biological function: Circ_0060640 expression is higher in anterior lens capsule tissues from human cataractous eyes and TGF-beta2-stimulated hLECs cells line SRA01/04. RNA interference of circ_0060640 could prevent SRA01/04 cells from TGF-beta2-induced cell proliferation, migration and invasion, accompanied with decreased N-cadherin and alpha-smooth muscle actin and increased E-cadherin.
Molecular mechanism: circ_0060640 directly controls microRNA (miR)-214-3p expression and then regulates gene expression of collagen type I alpha2 chain (COL1A2). Notably, COL1A2 inhibition is underlying the protective role of circ_0060640 silencing and hsa-miR-214-3p ectopic expression in TGF-beta2-stimulated SRA01/04 cells.
Survival: -
Supported No.:
 1
Description:

Circ_0060640 is a novel cataract-related gene and its silencing could block TGF-beta2-evoked hLECs proliferation, motility and EMTin vitrovia targeting miR-214-3p-COL1A2 axis. Therefore, targeting circ_0060640 via RNA interference might be a treatment strategy for PCO development.
Other information
Title:

Interfering Hsa_circRNA_0060640 Suppresses TGF-beta2-Induced Proliferation, Motility and EMT in Human Lens Epithelium Cells by Targeting miR-214-3p and Collagen Type I alpha2 Chain.

Journal: Curr Eye Res
Published: 2022/4/9
PubMed ID: 35392747