circRNA basic information
circBase ID: -
Name: hsa_circ_CEP128
Synonym: Circ-CEP128
Host Gene: hsa-miR-432-5p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human CC cell lines (Hela, CaSki), normal cervical epithelial cell line (Ect1/E6E7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MCL1.
Associated microRNA: hsa-miR-432-5p
Biological function: Circ-CEP128 had highly expression in CC tumor tissues and cells. Silencing of circ-CEP128 could enhance the paclitaxel sensitivity of CC cells by decreasing cell growth, migration, and invasion.
Molecular mechanism: knockdown of circ-CEP123 reduced CC tumor growth and promoted the paclitaxel sensitivity of CC tumors. hsa-miR-432-5p was found to be sponged by circ-CEP128, and its inhibitor could reverse the promoting function of circ-CEP128 silencing on the paclitaxel sensitivity of CC cells. Additionally, MCL1 was a target of hsa-miR-432-5p, and circ-CEP128 could sponge hsa-miR-432-5p to regulate MCL1. Besides, overexpressed MCL1 also could reverse the enhancing effect of hsa-miR-432-5p on the paclitaxel sensitivity of CC cells.
Survival: -
Supported No.:
 1
Description:

the present study showed that circ-CEP128 silencing could increase the paclitaxel sensitivity of CC by regulating the miR-432-5p/MCL1 axis.
Other information
Title:

Downregulation of Circ-CEP128 Enhances the Paclitaxel Sensitivity of Cervical Cancer Through Regulating miR-432-5p/MCL1.

Journal: Biochem Genet
Published: 2022/4/9
PubMed ID: 35391656