circRNA basic information
circBase ID: hsa_circ_0001445
Name: -
Synonym: Circ_0001445
Host Gene: hsa-miR-208b-5p
 
 
 
Disease basic information
DO ID:
 3393
DO name: coronary artery disease
Disease details: coronary artery disease
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human primary aortic endothelial cells (HAECs, PCS-100-011)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-208b-5p
Biological function: Circ_0001445 and ABCG1 were decreased, and miR-208b-5p was increased in CAD patients and ox-LDL-treated HAECs. Also, circ_0001445 overexpression could weaken ox-LDL-triggered HAEC injury by boosting proliferation, migration, and repressing inflammation and extracellular matrix (ECM).
Molecular mechanism: circ_0001445 directly targeted hsa-miR-208b-5p. Furthermore, hsa-miR-208b-5p mediated the modulation of circ_0001445 in ox-LDL-induced HAEC injury. ABCG1 acted as a direct target of hsa-miR-208b-5p, and the downregulation of hsa-miR-208b-5p relieved ox-LDL-induced HAEC damage by interacting with ABCG1. Additionally, circ_0001445 regulated ABCG1 expression by sponging hsa-miR-208b-5p.
Survival: -
Supported No.:
 2
Description:

Circ_0001445 could abate ox-LDL-mediated HAEC damage by the miR-208b-5p/ABCG1 axis, providing a novel insight into the pathogenesis and treatment of CAD.
Other information
Title:

Circular RNA circ_0001445 alleviates the ox-LDL-induced endothelial injury in human primary aortic endothelial cells through regulating ABCG1 via acting as a sponge of miR-208b-5p.

Journal: Gen Thorac Cardiovasc Surg
Published: 2022/4/9
PubMed ID: 35391605