circRNA basic information
circBase ID: hsa_circ_0020123
Name: -
Synonym: Circ_0020123
Host Gene: hsa-miR-512-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NSCLC cell lines (A549, H1299, PC_9), normal cell line (16HBE), human umbilical vein endothelial cell line (HUVEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CORO1C.
Associated microRNA: hsa-miR-512-3p
Biological function: Circ_0020123 expression was aberrantly upregulated in NSCLC tissues and cell lines. Circ_0020123 interference markedly restrained cell proliferation, migration, invasion, angiogenesis and autophagy and induced cell apoptosis of NSCLC cells. Circ_0020123 knockdown suppressed xenograft tumor growth in vivo.
Molecular mechanism: Circ_0020123 knockdown suppressed xenograft tumor growth in vivo. Circ_0020123 acted as a molecular sponge for hsa-miR-512-3p. Circ_0020123 silencing-induced effects in NSCLC cells were largely reversed by the knockdown of hsa-miR-512-3p. hsa-miR-512-3p interacted with the 3 untranslated region (3UTR) of CORO1C. CORO1C overexpression largely reversed hsa-miR-512-3p accumulation-induced influences in NSCLC cells. Circ_0020123 positively regulated CORO1C expression by sponging hsa-miR-512-3p in NSCLC cells.
Survival: -
Supported No.:
 9
Description:

Circ_0020123 aggravated NSCLC progression by binding to miR-512-3p to induce CORO1C expression, which provided new potential targets for the treatment of NSCLC.
Other information
Title:

Circ_0020123 plays an oncogenic role in non-small cell lung cancer depending on the regulation of miR-512-3p/CORO1C.

Journal: Thorac Cancer
Published: 2022/4/8
PubMed ID: 35388975