circRNA basic information
circBase ID: -
Name: hsa_circ_VCAN
Synonym: Circ_VCAN
Host Gene: hsa-miR-146b-5p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A172, U251 cells.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: NFIB
Associated microRNA: hsa-miR-146b-5p
Biological function: Sevoflurane (Sev) inhibited proliferation, migration, invasion, and elevated apoptosis of A172 and U251 cells. Sevoflurane treatment inhibited the expression of circ_VCAN and NFIB, but elevated the expression of miR-146b-5p in glioma cells. Overexpression of circ_VCAN alleviated the inhibition effects of sevoflurane on the malignant phenotypes of glioma in vitro and in vivo.
Molecular mechanism: hsa-miR-146b-5p is a target of circ_VCAN and negatively regulated NFIB expression. Overexpression of hsa-miR-146b-5p partly reversed the effects of circ_VCAN in Sev-treated glioma cells. Furthermore, hsa-miR-146b-5p deletion enhanced glioma progression in sevoflurane treated glioma cells by targeting NFIB. Moreover, circ_VCAN could upregulate NFIB expression by sponging hsa-miR-146b-5p in Sev-treated glioma cells.
Survival: -
Supported No.:
 3
Description:

Sevoflurane alleviated proliferation, migration and invasion, but enhanced apoptosis of glioma cells through regulating circ_VCAN/miR-146b-5p/NFIB axis.
Other information
Title:

Sevoflurane inhibits the malignant phenotypes of glioma through regulating miR-146b-5p/NFIB axis.

Journal: Metab Brain Dis
Published: 2022/4/8
PubMed ID: 35386035