circRNA basic information
circBase ID: -
Name: hsa_circ_LDLR
Synonym: CircLDLR
Host Gene: hsa-miR-26-5p
 
 
 
Disease basic information
DO ID:
 3393
DO name: coronary artery disease
Disease details: coronary artery disease
Species: human
Species details: human
Sample type: cell line
Sample type details: normal human T/G HA-VSMC
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: KDM6A
Associated microRNA: hsa-miR-26-5p
Biological function: VSMCs were transfected with miR-26-5p mimic/inhibitor or OE KDM6A. Cell proliferation and apoptosis were assessed.
Molecular mechanism: Luciferase reporter gene assays were used to examine interactions between hsa-miR-26-5p and KDM6A in VSMCs. Downregulation of circLDLR was associated with increased hsa-miR-26-5p in coronary artery disease tissues. In addition, circLDLR could inhibit cell proliferation and promote cell apoptosis by regulating hsa-miR-26-5p. Moreover, the overexpression of KDM6A reduced VSMCs proliferation and increased apoptosis in an hsa-miR-26-5p/circLDLR axis-dependent manner.
Survival: -
Supported No.:
 1
Description:

CircLDLR modulates the proliferation and apoptosis of VSMCs through miR-26-5p/KDM6A axis.
Other information
Title:

CircLDLR Modulates the Proliferation and Apoptosis of Vascular Smooth Muscle Cells in Coronary Artery Disease Through miR-26-5p/KDM6A Axis.

Journal: J Cardiovasc Pharmacol
Published: 2022/4/7
PubMed ID: 35384910