circRNA basic information
circBase ID: hsa_circ_0007841
Name: -
Synonym: Circ_0007841
Host Gene: hsa-miR-532-5p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human OC cell lines (A2780, SKOV3), human ovarian surface epithelial cells (HOSEPiC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-532-5p
Biological function: Circ_0007841 and NFIB expression were upregulated, whereas miR-532-5p was downregulated in DDP-resistant OC tissues and cells compared with controls. Circ_0007841 silencing improved DDP sensitivity, inhibited cell proliferation, invasion and migration, but induced cell apoptosis in DDP-resistant OC cells.
Molecular mechanism: Circ_0007841 acted as a hsa-miR-532-5p sponge and regulated DDP resistance and OC cell malignancy through hsa-miR-532-5p in DDP-resistant OC cells. Besides, the overexpression of NFIB, a target of hsa-miR-532-5p, remitted hsa-miR-532-5p-mediated effects in DDP-resistant OC cells. Circ_0007841 depletion conferred DDP sensitivity to DDP-resistant OC cells in vivo. Further, circ_0007841 was secreted from DDP-resistant OC cells through being packaged into exosomes.
Survival: -
Supported No.:
 1
Description:

Circ_0007841 conferred DDP resistance to DDP-resistant OC cells through the miR-532-5p/NFIB axis, suggesting the potential of circ_0007841 as a therapeutic target for OC.
Other information
Title:

Circ_0007841 knockdown confers cisplatin sensitivity to ovarian cancer cells by down-regulation of NFIB expression in a miR-532-5p-dependent manner.

Journal: J Chemother
Published: 2022/4/6
PubMed ID: 35380509