circRNA basic information
circBase ID: hsa_circ_0061140
Name: -
Synonym: circ_0061140
Host Gene: hsa-miR-653
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human LAUD cell lines (A549, NCI-H23, H1975, H1299), a normal human bronchial epithelial cell line (HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: hexokinase
Associated microRNA: hsa-miR-653
Biological function: circ_0061140 level was elevated in LUAD samples, and the high level of circ_0061140 was related to poor survival rate of LUAD patients. Circ_0061140 deletion inhibited glycolysis, migration and invasion of hypoxia-treated LUAD cells.
Molecular mechanism: circ_0061140 could modulate HK2 level by absorbing hsa-miR-653. Furthermore, hsa-miR-653 silence or HK2 addition neutralized the effects of circ_0061140 knockdown on LUAD progression under hypoxia.
Survival: poor
Supported No.:
 1
Description:

circ_0061140 accelerated hypoxia-triggered glycolysis, migration and invasion in LUAD cells via downregulating miR-653 and increasing HK2 expression.
Other information
Title:

Circular RNA circ_0061140 accelerates hypoxia-induced glycolysis, migration, and invasion in lung adenocarcinoma through the microRNA-653/hexokinase 2 (HK2) axis.

Journal: Bioengineered
Published: 2022/4/6
PubMed ID: 35379058