circRNA basic information
circBase ID: -
Name: hsa_circ_SSU72
Synonym: circSSU72
Host Gene: hsa-miR-451a
 
 
 
Disease basic information
DO ID:
 1781
DO name: thyroid gland cancer
Disease details: thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human thyroid normal epithelial cell line (Nthy-ori 3-1), human PTC cell lines (B-CPAP, KTC-1, K1, IHH-4, TPC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: S1PR2
Associated microRNA: hsa-miR-451a
Biological function: circSSU72 was upregulated in PTC; circSSU72 knockdown inhibited PTC cell proliferation, migration, and invasion.
Molecular mechanism: circSSU72 could negatively regulate hsa-miR-451a by functioning as a sponge. circSSU72 promoted PTC cell proliferation, migration, and invasion by targeting hsa-miR-451ain vitro. We further found that hsa-miR-451a inhibited PTC cell proliferation, migration, and invasion by regulating S1PR2. Overall, the circSSU72/hsa-miR-451a/S1PR2 axis might influence PTC cell proliferation, migration, and invasion.
Survival: -
Supported No.:
 1
Description:

circSSU72 (hsa_circ_0009294)/miR-451a/S1PR2 axis may promote cell proliferation, migration, and invasion in PTC. Thus, circSSU72 may serve as a potential biomarker and therapeutic target for PTC.
Other information
Title:

circSSU72 Promotes Cell Proliferation, Migration and Invasion of Papillary Thyroid Carcinoma Cells by Targeting miR-451a/S1PR2 Axis.

Journal: Front Cell Dev Biol
Published: 2022/4/5
PubMed ID: 35372340