circRNA basic information
circBase ID: -
Name: hsa_circ_ASPM
Synonym: CircASPM
Host Gene: hsa-miR-130b-3p
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma multiforme
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: GSCs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F1
Associated microRNA: hsa-miR-130b-3p
Biological function: CircASPM was overexpressed in GBM and promoted the tumorigenesis and proliferation of GSCs bothin vitroandin vivo.
Molecular mechanism: circASPM up-regulated the expression of E2F1 in GSCs via hsa-miR-130b-3p sponging. We furtherly demonstrated that circAPSM could promote the GSCs proliferation via E2F1 up-regulating. Therefore, our study identified a novel circRNA and its possible mechanism in the development and tumorigenesis of GBM.
Survival: -
Supported No.:
 1
Description:

CircASPM can promote GBM progression via regulating miR-130b-3p/E2F1 axis, suggesting that circAPSM could provide an effective biomarker for GBM diagnosis and prognostic evaluation and possibly being used for molecular targeted therapy.
Other information
Title:

Circular RNA circASPM promotes the progression of glioblastoma by acting as a competing endogenous RNA to regulate miR-130b-3p/E2F1 axis.

Journal: J Cancer
Published: 2022/4/5
PubMed ID: 35371308