circRNA basic information
circBase ID: -
Name: hsa_circ_PSAP
Synonym: CircPSAP
Host Gene: hsa-miR-331-3p
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: multiple myeloma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MM1.S, NCI-H929, U266B1, OPM-2
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-331-3p
Biological function: CircPSAP was overexpressed in human MM and high levels of circPSAP predicted poor prognosis in MM patients. CircPSAP depletion repressed cell proliferation and promoted apoptosis and BTZ sensitivity.
Molecular mechanism: -
Survival: poor
Supported No.:
 1
Description:

Our findings highlight a novel mechanism, in which circPSAP functions as a miR-331-3p sponge to impact MM cell proliferation, apoptosis and BTZ sensitivity by regulating HDAC4 expression.
Other information
Title:

Circular RNA circPSAP functions as an efficient miR-331-3p sponge to regulate proliferation, apoptosis and bortezomib sensitivity of human multiple myeloma cells by upregulating HDAC4.

Journal: J Pharmacol Sci
Published: 2022/4/5
PubMed ID: 35369902