circRNA basic information
circBase ID: -
Name: hsa_circ_GSE1
Synonym: circGSE1
Host Gene: hsa-miR-323-5p
 
 
 
Disease basic information
DO ID:
 1287
DO name: cardiovascular system disease
Disease details: cardiovascular disease
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: mouse aortic endothelial cells (MAECs)
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
DN
Associated gene: NRP1
Associated microRNA: hsa-miR-323-5p
Biological function: circGSE1 could promote the proliferation, migration and tube formation of OECsin vitro. In a mouse model of femoral artery ligation and ischemia, circGSE1 promoted blood flow recovery and angiogenesis in the ischemic limbs of ageing mice.
Molecular mechanism: overexpressing circGSE1 reduced hsa-miR-323-5p expression, increased neuropilin-1 (NRP1) expression, and promoted proliferation, migration, and tube formation in OECs, while knocking down circGSE1 increased hsa-miR-323-5p expression, reduced NRP1 expression, and inhibited proliferation, migration, and tube formation in YECs.
Survival: -
Supported No.:
 1
Description:

circGSE1 may act through the miR-323-5p/NRP1 axis and promote endothelial angiogenesis in mice. Finally, the circGSE1/miR-323-5p/NRP1 axis could serve as a potential and promising therapeutic target for angiogenesis during ageing.
Other information
Title:

Circular RNA circGSE1 promotes angiogenesis in ageing mice by targeting the miR-323-5p/NRP1 axis.

Journal: Aging (Albany NY)
Published: 2022/4/3
PubMed ID: 35366240