circRNA basic information
circBase ID: -
Name: hsa_circ_ZDBF2
Synonym: CircZDBF2
Host Gene: hsa-miR-500b-5p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: cell line
Sample type details: OSCC cell lines (SCC9, SCC15, SCC25)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-500b-5p
Biological function: CircZDBF2 expressed at a high level in OSCC cells and it accelerated OSCC cell proliferation, migration, invasion as well as EMT (epithelial-mesenchymal transition) process.
Molecular mechanism: circZDBF2 sponged hsa-miR-362-5p and hsa-miR-500b-5p in OSCC cells to release their target ring finger protein 145 (RNF145). RNF145 expressed at a high level in OSCC cells and circZDBF2 facilitated RNF145 transcription by recruiting the transcription factor CCAAT enhancer binding protein beta (CEBPB). Moreover, RNF145 activated NF¦ĘB (nuclear factor kappa B) signaling pathway and regulated IL-8 (C-X-C motif chemokine ligand 8) transcription.
Survival: -
Supported No.:
 1
Description:

CircZDBF2 up-regulated RNF145 expression by sponging miR-362-5p and miR-500b-5p and recruiting CEBPB, thereby promoting OSCC progression via NF¦ĘB signaling pathway. The findings recommend circZDBF2 as a probable therapeutic target for OSCC.
Other information
Title:

CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFkappaB signaling pathway.

Journal: J Transl Med
Published: 2022/4/3
PubMed ID: 35365168