circRNA basic information
circBase ID: -
Name: -
Synonym: circ3323
Host Gene: -
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: BIU-87 cells, 5637 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: The expression of circ3323 was higher in BCa tissues and cells than in normal samples. Experiments in vitro showed that the knockdown of circ3323 inhibited cell proliferation and impeded the metastasis of BCa cells.
Molecular mechanism: circ3323 acts as a sponge for hsa-miR-186-5p and promotes host gene APPs expression. Clinically, circ3323 predicts worse overall survival of BCa patients, indicating its prognostic value.
Survival: poor
Supported No.:
 1
Description:

circ3323 modulates metastasis of BCa through miR-186-5p/APP axis and may serve as a promising prognostic biomarker for BCa, which provides novel insights into treatment of BCa.
Other information
Title:

circ3323 Motivates Host Gene to Promote the Aggressiveness of Bladder Cancer.

Journal: Biochem Genet
Published: 2022/4/2
PubMed ID: 35362879