circRNA basic information
circBase ID: hsa_circ_0125803
Name: -
Synonym: circ0125803
Host Gene: hsa-miR-197-5p
 
 
 
Disease basic information
DO ID:
 769
DO name: neuroblastoma
Disease details: neuroblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: SK-N-SH, IMR32, GI-LI-N, HUVEC
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-197-5p
Biological function: hsa_circ_0125803 (circ0125803) as an extremely upregulated circRNA in neuroblastoma samples. Knockdown of circ0125803 significantly decreased the growth rate and invasion rate in neuroblastoma.
Molecular mechanism: Upregulation of circ0125803 promotes the neuroblastoma progression by blocking hsa-miR-197-5p and upregulating E2F1 expression.
Survival: -
Supported No.:
 1
Description:

the biological function of the circ0125803-miR-197-5p-E2F1 axis in neuroblastoma metastasis and growth.
Other information
Title:

circ0125803 facilitates tumor progression by sponging miR-197-5p and upregulating E2F1 in neuroblastoma.

Journal: Pathol Res Pract
Published: 2022/4/1
PubMed ID: 35358781