circRNA basic information
circBase ID: -
Name: hsa_circ_LONP2
Synonym: circLONP2
Host Gene: hsa-miR-584-5p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: BC cell lines (RT4, T24, EJ, UMUC3, 5637), uroepithelium cell lines (SV-HUC-1)
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-584-5p
Biological function: CircLONP2 was significantly upregulated in precancerous BC tissues and BC cells. CircLONP2 depletion inhibited cell viability, proliferation, and invasion of BC cell lines, which could be partially rescued by miR-584-5p inhibitor.
Molecular mechanism: Further experiments indicated that hsa-miR-584-5p regulates cell viability, proliferation, and invasion via directly targeting YAP1.
Survival: -
Supported No.:
 1
Description:

circLONP2 plays an oncogenic function in BC by regulating miR-584-5p/YAP1 axis, and its interaction with miR-584-5p provides a potential strategy to target BC.
Other information
Title:

Circular RNA LONP2 regulates proliferation, invasion, and apoptosis of bladder cancer cells by sponging microRNA-584-5p.

Journal: Bioengineered
Published: 2022/4/1
PubMed ID: 35358000