circRNA basic information
circBase ID: hsa_circ_0008717
Name: -
Synonym: Circ_0008717
Host Gene: hsa-miR-217
 
 
 
Disease basic information
DO ID:
 4450
DO name: renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: RCC cell lines (A498, CAL54), normal kidney cells (HK-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-217
Biological function: Circ_0008717 was upregulated in RCC tissues and cells. Silencing circ_0008717 suppressed RCC cell proliferation, migration, invasion and glycolysis but promoted cell apoptosis. MiR-217 was a target of circ_0008717 and bound to the FBXO17 3 untranslated region. The expression of FBXO17 was positively regulated by circ_0008717 but impaired by miR-217 reintroduction.
Molecular mechanism: The inhibitory effects of circ_0008717 knockdown on RCC cell malignant behaviors were reversed by hsa-miR-217 inhibition or FBXO17 overexpression. Circ_0008717 knockdown inhibited tumor growth in vivo by regulating hsa-miR-217 and FBXO17.
Survival: -
Supported No.:
 1
Description:

Circ_0008717 aggravated the progression of RCC by activating FBXO17 through targeting miR-217, which provided a novel mechanism for circ_0008717 to participate in RCC progression.
Other information
Title:

Circ_0008717 promotes renal cell carcinoma progression by upregulating FBXO17 via targeting miR-217.

Journal: J Gene Med
Published: 2022/4/1
PubMed ID: 35357059