circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_101277
Host Gene: hsa-miR-370
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human colonic epithelial cells (CCD 841 CoN), colorectal cell lines (LoVo, HT-29, HCT116, SW480, SW620)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IL-6
Associated microRNA: hsa-miR-370
Biological function: circRNA_101277 was increased in CRC tissues compared with control samples. circRNA_101277 overexpression was evident in CRC cells, and knockdown of this circRNA suppressed cellular proliferation and cisplatin resistance in these cancer cells.
Molecular mechanism: circRNA_101277 was found to function by sequestering hsa-miR-370, thereby upregulating the hsa-miR-370 target gene IL-6 and promoting cisplatin resistance via this hsa-miR-370/IL-6 axis.
Survival: -
Supported No.:
 1
Description:

highlight circRNA_101277 as a novel driver of CRC cell cisplatin resistance that functions by sequestering miR-370 and thereby enhancing IL-6 expression. These findings suggest that this circRNA_101277/miR-370/IL-6 axis may represent a critical axis of chemoresistance in CRC that can be targeted to diagnose and/or treat this cancer.
Other information
Title:

circRNA_101277 Influences Cisplatin Resistance of Colorectal Cancer Cells by Modulating the miR-370/IL-6 Axis.

Journal: Genet Res (Camb)
Published: 2022/4/1
PubMed ID: 35356749