circRNA basic information
circBase ID: -
Name: hsa_circ_ZFR
Synonym: Circ_ZFR
Host Gene: hsa-miR-223-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: BC cell lines (MCF_7, MDA_MB_231, BT_549, T_47D), normal mammary epithelial cell line (MCF_10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-223-3p
Biological function: The expression levels of circ_ZFR and FABP7 were higher in BC tissues and cell lines, whereas miR-223-3p expression was lower. Knockdown of circ_ZFR or FABP7 in BC cells reduced proliferation, migration, invasion, and epithelial mesenchymal transition (EMT), and induced apoptosis in vitro, whereas the opposite effects were observed in circ_ZFR-overexpressed cells.
Molecular mechanism: circ_ZFR might act as a sponge for hsa-miR-223-3p to regulate FABP7 expression, thereby promoting the progression of BC cells in vitro and in vivo.
Survival: -
Supported No.:
 2
Description:

Circ_ZFR might act as a miRNA sponge for miR-223-3p to regulate FABP7, thereby promoting proliferation, migration, invasion, and EMT of BC cells, and inhibiting cell apoptosis.
Other information
Title:

Circ_ZFR affects FABP7 expression to regulate breast cancer progression by acting as a sponge for miR-223-3p.

Journal: Thorac Cancer
Published: 2022/4/1
PubMed ID: 35355424