circRNA basic information
circBase ID: hsa_circ_0000263
Name: -
Synonym: Circ_0000263
Host Gene: hsa-miR-1179
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human CC cells (HeLa, SiHa)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ABL2
Associated microRNA: hsa-miR-1179
Biological function: Circ_0000263 was highly expressed in CC tumor tissues. Silencing of circ_0000263 suppressed CC cell proliferation and increased apoptosis.
Molecular mechanism: Circ_0000263 served as a sponge for hsa-miR-1179, and hsa-miR-1179 inhibitor reversed the regulation of si-circ_0000263 on CC cell proliferation and apoptosis. ABL2 could be targeted by hsa-miR-1179, and circ_0000263 could sponge hsa-miR-1179 to regulate ABL2. Overexpression of ABL2 reversed the anti-proliferation and pro-apoptosis roles of hsa-miR-1179 in CC cells. In addition, circ_0000263 knockdown reduced CC tumor growth by hsa-miR-1179/ABL2 axis.
Survival: -
Supported No.:
 2
Description:

Circ_0000263 exerted an oncogene role in CC, which suggested that circ_0000263 might be a promising therapeutic target for CC.
Other information
Title:

Circ_0000263 facilitates the proliferation and inhibits the apoptosis of cervical cancer depending on the regulation of miR-1179/ABL2 axis.

Journal: Reprod Sci
Published: 2022/4/1
PubMed ID: 35355231