circRNA basic information
circBase ID: hsa_circ_0001747
Name: -
Synonym: circ_0001747
Host Gene: hsa-miR-199b-3p
 
 
 
Disease basic information
DO ID:
 5844
DO name: myocardial infarction
Disease details: acute myocardial infarction
Species: human
Species details: human
Sample type: cell line
Sample type details: mouse myocardial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MCL1
Associated microRNA: hsa-miR-199b-3p
Biological function: H/R-induced HL-1 dysfunction was attenuated by the incubation of exosomes derived from ADSCs, especially the exosomes with high amounts of circ_0001747.
Molecular mechanism: Circ_0001747 directly targeted miR-199b-3p in HL-1 cells. miR-199b-3p overexpression partly overturned exosomal circ_0001747-mediated protective effects in H/R-induced HL-1 cells.
Survival: -
Supported No.:
 1
Description:

ADSCs-derived exosomes with high amounts of circ_0001747 attenuated H/R-induced HL-1 dysfunction partly by targeting miR-199b-3p/MCL1 signaling.
Other information
Title:

Adipose-Derived Stem Cells-Derived Exosomes with High Amounts of Circ_0001747 Alleviate Hypoxia/Reoxygenation-Induced Injury in Myocardial Cells by Targeting MiR-199b-3p/MCL1 Axis.

Journal: Int Heart J
Published: 2022/4/1
PubMed ID: 35354755