circRNA basic information
circBase ID: -
Name: hsa_circ_PRKCH
Synonym: circ-PRKCH
Host Gene: hsa-miR-502-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human chondrocytes (CHON-001)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ADAMTS5
Associated microRNA: hsa-miR-502-5p
Biological function: Circ-PRKCH and ADAMTS5 expression levels were up-regulated, while miR-502-5p expression was down-regulated in OA cartilage tissues and IL-1beta-treated chondrocytes. Depletion of circ-PRKCH relieved IL-1beta-treated chondrocyte cell phenotypic changes by promoting cell proliferation and migration, as well as inhibiting apoptosis and inflammatory response.
Molecular mechanism: circ-PRKCH acted as a sponge for hsa-miR-502-5p to regulate ADAMTS5 expression, thereby contributing to IL-1beta-treated chondrocyte cell phenotypic changes. Moreover, exosomes derived from IL-1beta-treated chondrocytes could transfer circ-PRKCH across cells.
Survival: -
Supported No.:
 3
Description:

Circ-PRKCH contributed to IL-1beta-treated cell phenotypic changes in chondrocytesviamodulating miR-502-5p/ADAMTS5 pathway, which might provide a promising biomarker for OA treatment.
Other information
Title:

Knockdown of circ-PRKCH alleviates IL-1beta-treated chondrocyte cell phenotypic changes through modulating miR-502-5p/ADAMTS5 axis.

Journal: Autoimmunity
Published: 2022/3/31
PubMed ID: 35352613