circRNA basic information
circBase ID: -
Name: hsa_circ_SKA3
Synonym: circSKA3
Host Gene: hsa-miR-520
 
 
 
Disease basic information
DO ID:
 0050902
DO name: medulloblastoma
Disease details: medulloblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human medulloblastoma cell line (Daoy)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-520
Biological function: CircSKA3 depletion markedly suppressed Daoy cell viability, migration, invasion, and cell cycle progression. CircSKA3 overexpression induced the opposite effects.
Molecular mechanism: circSKA3 could decoyed hsa-miR-520 h, which targeted the 3 UTR of CDK6. circSKA3 expression in medulloblastoma tissues was negatively correlated with hsa-miR-520 h expression and positively correlated with CDK6 expression.
Survival: -
Supported No.:
 4
Description:

Rescue experiments revealed that miR-520 h down-modulation or CDK6 overexpression remarkably counteracted the inhibitory effect of circSKA3 knockdown on Daoy cells. circSKA3 facilitates medulloblastoma progression through miR-520 h/CDK6.
Other information
Title:

The Circular RNA circSKA3 Facilitates the Malignant Biological Behaviors of Medulloblastoma via miR-520 h/CDK6 Pathway.

Journal: Mol Biotechnol
Published: 2022/3/31
PubMed ID: 35352283