circRNA basic information
circBase ID: hsa_circ_0006089
Name: -
Synonym: circ_0006089
Host Gene: hsa-miR-361-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: human GC cells (AGS, HGC_27), normal gastric mucosa cells (GES_1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TGFB1.
Associated microRNA: hsa-miR-361-3p
Biological function: circ_0006089 had been found to be upregulated in GC tissues and cells, and it could act as an miR-361-3p sponge. circ_0006089 knockdown suppressed GC proliferation, metastasis, glycolysis, angiogenesis, and increased apoptosis, while this effect could be revoked by miR-361-3p inhibitor.
Molecular mechanism: TGFB1 was targeted by hsa-miR-361-3p, and its overexpression reversed the effects of hsa-miR-361-3p on GC cell function. Also, circ_0006089 promoted TGFB1 expression via sponging hsa-miR-361-3p. Animal experiments showed that silenced circ_0006089 inhibited GC tumorigenesis through the hsa-miR-361-3p/TGFB1 pathway.
Survival: -
Supported No.:
 4
Description:

the circ_0006089/miR-361-3p/TGFB1 axis contributed to GC progression, confirming that circ_0006089 might be a potential therapeutic target for GC.
Other information
Title:

circ_0006089 promotes gastric cancer growth, metastasis, glycolysis, and angiogenesis by regulating miR-361-3p/TGFB1.

Journal: Cancer Sci
Published: 2022/3/30
PubMed ID: 35347818