circRNA basic information
circBase ID: -
Name: hsa_circ_Rbms1
Synonym: CircRbms1
Host Gene: hsa-miR-742-3p
 
 
 
Disease basic information
DO ID:
 5844
DO name: myocardial infarction
Disease details: myocardial Infarction
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: mouse cardiomyocytes (H9c2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXO1
Associated microRNA: hsa-miR-742-3p
Biological function: CircRbms1 was upregulated in the heart tissues of MI mice and hypoxia-induced cardiomyocytes. Hypoxia induced cardiomyocyte injury by suppressing cell viability, migration, and invasion, and promoting apoptosis. Function experiments showed that circRbms1 overexpression aggravated hypoxia-induced cardiomyocyte injury, while its silencing relieved cardiomyocyte injury induced by hypoxia.
Molecular mechanism: circRbms1 sponged hsa-miR-742-3p. hsa-miR-742-3p overexpression alleviated hypoxia-induced cardiomyocyte injury, and its inhibitor reversed the suppressive effect of circRbms1 silencing on hypoxia-induced cardiomyocyte injury. Further experiments showed that FOXO1 was a target of hsa-miR-742-3p, and its expression was positively regulated by circRbms1. The inhibitory effect of hsa-miR-742-3p on hypoxia-induced cardiomyocyte injury was reversed by FOXO1 overexpression.
Survival: -
Supported No.:
 1
Description:

CircRbms1 regulated the miR-742-3p/FOXO1 axis to mediate hypoxia-induced cardiomyocyte injury, suggesting that circRbms1 might be an effective target for MI treatment.
Other information
Title:

CircRbms1 knockdown alleviates hypoxia-induced cardiomyocyte injury via regulating the miR-742-3p/FOXO1 axis.

Journal: Cell Mol Biol Lett
Published: 2022/3/30
PubMed ID: 35346026