circRNA basic information
circBase ID: hsa_circ_0041732
Name: -
Synonym: Circ_0041732
Host Gene: hsa-miR-149-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human breast cancer cell lines (BT-549, MDA-MB-231), human normal breast epithelial cell line (MCF-10A), human umbilical vein endothelial cell line (HUVEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FGF5
Associated microRNA: hsa-miR-149-5p
Biological function: Circ_0041732 andFGF5expression were significantly upregulated, whereas miR-149-5p was downregulated in TNBC tissues and cells compared with normal breast tissues and cells
Molecular mechanism: Circ_0041732 silencing inhibited TNBC cell proliferation, migration, invasion, and tube formation, but induced apoptosis. Additionally, circ_0041732 regulated TNBC cell tumor properties by binding to hsa-miR-149-5p. hsa-miR-149-5p also modulated TNBC cell tumor properties by targetingFGF5. Furthermore, circ_0041732 knockdown hindered tumor formation in vivo.
Survival: -
Supported No.:
 2
Description:

Circ_0041732 silencing suppressed TNBC cell tumor properties by decreasingFGF5expression through miR-149-5p. This finding demonstrated that circ_0041732 had the potential as a therapeutic target for TNBC.
Other information
Title:

Circ_0041732 regulates tumor properties of triple-negative breast cancer cells by the miR-149-5p/FGF5 pathway.

Journal: Int J Biol Markers
Published: 2022/3/29
PubMed ID: 35341378