circRNA basic information
circBase ID: -
Name: hsa_circ_NR3C1
Synonym: CircNR3C1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: SGC-7901, AGS, SNU-16, BGC-823 cell lines, gastric mucosal epithelial cells (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: A low level of circNR3C1 predicted high incidences of lymphatic or distant metastasis of GC. Knockdown of circNR3C1 enhanced proliferation and migration abilities in BGC-823 cells, whereas overexpression of circNR3C1 yielded the opposite results in AGS cells.
Molecular mechanism: circNR3C1 downregulated mTOR and AKT in GC cells. In addition, induction of the AKT activator could reverse the attenuated proliferative and migratory potentials in GC cells overexpressing circNR3C1. On the contrary, induction of the AKT inhibitor reversed the stimulated malignant phenotypes of GC with circNR3C1 knockdown.
Survival: -
Supported No.:
 1
Description:

circNR3C1 inhibits GC to proliferate and migrate by inactivating the AKT/mTOR signaling. It is also closely linked to GC metastasis.
Other information
Title:

CircNR3C1 Alleviates Gastric Cancer Development by Inactivating AKT/mTOR.

Journal: J Healthc Eng
Published: 2022/3/29
PubMed ID: 35340241