circRNA basic information
circBase ID: hsa_circ_0043533
Name: -
Synonym: circ_0043533
Host Gene: hsa-miR-1179
 
 
 
Disease basic information
DO ID:
 11612
DO name: polycystic ovary syndrome
Disease details: polycystic ovary syndrome
Species: human
Species details: human
Sample type: cell line
Sample type details: human granule-like tumor cell lines (KGN, COV434)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1179
Biological function: knockdown of circ_0043533 remarkably inhibited the cell viability and proliferation and promoted the apoptosis of insulin-treated COV434 and KGN cells, respectively. Meanwhile, circ_0043533 knockdown could down-regulate the Bcl-2, CDK2, and Cyclin D1 expressions, and up-regulate the Bax levels.
Molecular mechanism: circ_0043533 acted as a sponge to absorb hsa-miR-1179. Interestingly, hsa-miR-1179 inhibition remarkably attenuated the effect of circ_0043533 silence on cell proliferation and apoptosis in insulin-treated COV434 and KGN cells.
Survival: -
Supported No.:
 2
Description:

Circ_0043533 knockdown restrained the malignant progression of PCOS via targeting miR-1179. Our data suggested that circ_0043533 would serve as a novel therapeutic target for PCOS.
Other information
Title:

CircRNA circ_0043533 facilitates cell growth in polycystic ovary syndrome by targeting miR-1179.

Journal: Reprod Biol
Published: 2022/3/27
PubMed ID: 35338913