circRNA basic information
circBase ID: -
Name: hsa_circ_THBS1
Synonym: CircTHBS1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: HEK-293T cell line, human gastric epithelium cell line (GES-1), human GC cell lines (AGS, HGC-27, KATOIII, MKN-45, NCI-N87)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: The expression of circTHBS1 was significantly increased in GC and associated with poor prognosis. CircTHBS1 facilitated the malignant behavior and epithelial-to-mesenchymal transition of GC cells.
Molecular mechanism: circTHBS1 sponged hsa-miR-204-5p to promote the expression of Inhibin Subunit Beta A (INHBA). Moreover, circTHBS1 could enhance the HuR-mediated mRNA stability of INHBA, which subsequently activated the TGF-beta pathway.
Survival: -
Supported No.:
 2
Description:

Our research identified circTHBS1 as an oncogenic circRNA that enhances GC malignancy by elevating INHBA expression, providing new insight and a feasible target for the diagnosis and treatment of GC.
Other information
Title:

CircTHBS1 drives gastric cancer progression by increasing INHBA mRNA expression and stability in a ceRNA- and RBP-dependent manner.

Journal: Cell Death Dis
Published: 2022/3/27
PubMed ID: 35338119