circRNA basic information
circBase ID: hsa_circ_0008717
Name: -
Synonym: circ_0008717
Host Gene: hsa-miR-1287-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human NSCLC cell lines (A549, H1299), bronchial epithelial cells (BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: P21-activated
Associated microRNA: hsa-miR-1287-5p
Biological function: Circ_0008717 was highly expressed in NSCLC.
Molecular mechanism: circ_0008717 deficiency suppressed cell malignant phenotypes in NSCLCin vitroand in nude mice. Circ_0008717 sponged hsa-miR-1287-5p to elevate PAK2, a downstream target of hsa-miR-1287-5p. Silencing of hsa-miR-1287-5p blocked the antitumor effects of circ_0008717 knockdown in NSCLC cells. Besides, hsa-miR-1287-5p repressed cell oncogenic behaviors in NSCLC by targeting PAK2.
Survival: -
Supported No.:
 2
Description:

circ_0008717 was incorporated into exosomes in NSCLC cells. Circ_0008717 knockdown inhibited NSCLC tumorigenesis via miR-1287-5p/PAK2 axis, and the extracellular circulating circ_0008717 was transferred through incorporation in exosomes.
Other information
Title:

Cancer-released exosomal circular RNA circ_0008717 promotes cell tumorigenicity through microRNA-1287-5p/P21-activated kinase 2 (PAK2) axis in non-small cell lung cancer.

Journal: Bioengineered
Published: 2022/3/26
PubMed ID: 35333693