| Detected method: |
Q
|
| Detected method confidence |
High
|
| Expression pattern: |
|
| Associated gene: |
HMGA2 |
| Associated microRNA: |
hsa-miR-198 |
| Biological function: |
Murine xenograft model was established to investigate the role of circ_0003340 and DEX in vivo. DEX exerted antitumor effects in esophagus cancer cells. DEX hindered proliferation and invasion while inducing apoptosis of esophagus cancer cells, which was abolished by circ_0003340 elevation, HMGA2 overexpression, or miR-198 silencing. |
| Molecular mechanism: |
hsa-miR-198 directly interacted with circ_0003340 and HMGA2 in esophagus cancer cells. Moreover, knockdown of circ_0003340 could improve the anticancer role of DEX in vivo. |
| Survival: |
- |
Supported
No.: |
3 |
| Description: |
DEX constrained cell carcinogenesis by regulating circ_0003340/miR-198/HMGA2 axis in esophagus cancer, providing an effective clinical implication for preventing the development of the esophagus cancer by the DEX. |