circRNA basic information
circBase ID: -
Name: hsa_circ_FOXK2
Synonym: CircFOXK2
Host Gene: hsa-miR-485-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: NSCLC cell lines (A549, H460), BEAS-2B
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PD-L1
Associated microRNA: hsa-miR-485-5p
Biological function: CircFOXK2 and PD-L1 levels were augmented in NSCLC. CircFOXK2 targeted miR-485-5p, which could bind to PD-L1. CircFOXK2 served a key role in NSCLC tumorigenesis and cytotoxicity of CD8+ T cells.
Molecular mechanism: hsa-miR-485-5p inhibition or PD-L1 overexpression abolished the inhibitory effects of circFOXK2 lack on NSCLC tumorigenesis and cytotoxicity of CD8+ T cells.
Survival: -
Supported No.:
 2
Description:

CircFOXK2 sponged miR-485-5p to stimulate PD-L1 and expedited NSCLC development.
Other information
Title:

CircFOXK2 enhances tumorigenesis and immune evasion in non-small cell lung cancer by miR-485-5p/PD-L1 axis.

Journal: Anticancer Drugs
Published: 2022/3/25
PubMed ID: 35324518