circRNA basic information
circBase ID: hsa_circ_0001093
Name: -
Synonym: Circ_0001093
Host Gene: hsa-miR-579-3p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ESCC cell lines (KYSE150, EC109, EC9706, KYSE30), human esophageal squamous epithelial cell line (Het-1)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: glutaminase
Associated microRNA: hsa-miR-579-3p
Biological function: we found that circ_0001093 expression was up-regulated in ESCC tissues and cell lines. Increased circ_0001093 expression predicted an unfavourable prognosis, and was associated with the lymph node metastasis, TNM staging and tumor size in ESCC tissues. Circ_0001093 knockdown suppressed cell proliferation, invasion, migration and glutamine metabolism of ESCC cells, while circ_0001093 over-expression showed the opposite effects.
Molecular mechanism: circ_0001093 acted as a competing endogenous RNA (ceRNA) by sponging hsa-miR-579-3p, thereby increasing GLS expression. Furthermore, the inhibitory effects of circ_0001093 knockdown on the invasion, migration and glutamine metabolism were partly rescued by hsa-miR-579-3p inhibition or GLS over-expression in ESCC cells. Additionally, hsa-miR-579-3p expression was down-regulated in ESCC tissues, while GLS expression was up-regulated.
Survival: -
Supported No.:
 1
Description:

first provides evidence that the circ_0001093/miR-579-3p/GLS regulatory network can affect glutamine metabolism and malignant phenotype of ESCC, which can further impact ESCC progression.
Other information
Title:

Circ_0001093 promotes glutamine metabolism and cancer progression of esophageal squamous cell carcinoma by targeting miR-579-3p/glutaminase axis.

Journal: J Bioenerg Biomembr
Published: 2022/3/25
PubMed ID: 35322289